Recombinant humaan TSLP-eiwit

TSLP is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c (+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. TSLP is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. Recombinant human TSLP protein, fused to His-tag at N-terminus, was expressed in E. coli.

Thymic stromal lymphopoietin

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.25 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

17.3 kDa (154aa)

TSLP, Thymic stromal lymphopoietin, ATGP2950-10 µg, ATGP2950-20 µg, ATGP2950-50 µg, ATGP2950-100 µg, ATGP2950-250 µg, ATGP2950-500 µg, ATGP2950-1 mg, ATGP2950-10, ATGP2950-20, ATGP2950-50, ATGP2950-100, ATGP2950-250, ATGP2950-500, ATGP2950-1

Datta A., et al. (2013) J. Immunol. 191 (9), 4867-4879

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Immunology

NP_149024

Q969D9

Human

YDFTNCD FEKIKAAYLS TISKDLITYM SGTKSTEFNN TVSCSNRPHC LTEIQSLTFN PTAGCASLAK EMFAMKTKAA LAIWCPGYSE TQINATQAMK KRRKRKVTTN KCLEQVSQLQ GLWRRFNRPL LKQQ