Recombinant humaan TWEAKR/TNFRSF12A eiwit

TNFRSF12A, also known as tumor necrosis factor receptor superfamily member 12A, is the sole signaling receptor for the proinflammatory cytokine TWEAK (TNFSF12) . It is a Downstream Target of the TGF-b Signaling Pathway and regulates Fibroblast Activation. It promotes oxidative stress through NADPH oxidase activation in macrophages. It is responsible for TWEAK-induced proliferation of endothelial cells and angiogenesis. Recombinant human TNFRSF12A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor-inducible immediate-early response protein 14, FGF-inducible 14, Tweak-receptor, TweakR, CD266, FN14

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

32.6 kDa (292aa)

CD 266, CD266, FGF inducible 14, FGF-inducible 14, Fibroblast growth factor-inducible immediate-early response protein 14, FN14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, TWEAK R, Tweak receptor, TWEAK TNFRSF12, TWEAKR, Tweak-receptor, ATGP3624-10 µg, ATGP3624-20 µg, ATGP3624-50 µg, ATGP3624-100 µg, ATGP3624-250 µg, ATGP3624-500 µg, ATGP3624-1 mg, ATGP3624-010, ATGP3624-020, ATGP3624-050, ATGP3624-100, ATGP3624-250, ATGP3624-500, ATGP3624-01M

Nakayama M., et al. (2003) J Immunol. 170:341-348.; ; Madrigal-Matute J., et al. (2015) Cardiovasc Res. 108:139-147.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 1mM DTT, 20% glycerol

Cardiovascular

NP_057723

Q9NP84

Human

Glu28