Recombinant humaan u-plasminogeenactivator/urokinase-eiwit

PLAU, also known as urokinase-type plasminogen activator, is a serine protease which converts plasminogen to plasmin. It is a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in complement activation, cell migration, wound healing, and generation of localized extracellular proteolysis during tissue remodeling, pro-hormone conversion, carcinogenesis and neoplasia. Recombinant human PLAU, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Urokinase-type plasminogen activator, PLAU, ATF, BDPLT5, QPD, u-PA, UPA, URK, Endothelial plasminogen activator inhibitor, PAI, PAI 1, PLANH1, Plasminogen activator inhibitor 1, Plasminogen activator urinary, Plasminogen activator urokinase, Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, Serpin E1, Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, SERPINE1, u PA, U plasminogen activator, UPA, URK, Urokinase type plasminogen activator

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

47.4 kDa (419aa)

U-Plasminogen Activator, Urokinase, Urokinase-type plasminogen activator, PLAU, ATF, BDPLT5, QPD, u-PA, UPA, URK, Endothelial plasminogen activator inhibitor, PAIPAI 1, PLANH1, Plasminogen activator inhibitor 1, Plasminogen activator urinary, Plasminogen activator urokinase, Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, Serpin E1, Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, SERPINE1, u PA, U plasminogen activator, UPA, URK, Urokinase type plasminogen activator, ATGP3383-10 µg, ATGP3383-20 µg, ATGP3383-50 µg, ATGP3383-100 µg, ATGP3383-250 µg, ATGP3383-500 µg, ATGP3383-1 mg, ATGP3383-10, ATGP3383-20, ATGP3383-50, ATGP3383-100, ATGP3383-250, ATGP3383-500, ATGP3383-1

Crippa MP., et al. (2007) Int J Biochem Cell Biol. 39:690-694.; ; Kunamneni A., et al. (2008) Recent Pat Cardiovasc Drug Discov. 3:45-58.

Hirayama S, et al. Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation. (FEBS Open Bio. 2022) {https://pubmed.ncbi.nlm.nih.gov/35298875/}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Enzymes & Proteases

NP_002649.1

P00749

Human

Ser21