Recombinant humaan ULBP-3 eiwit

ULBP-3, also known as NKG2D ligand 3, is ligands for natural-killer group 2, member D (NKG2D) receptor. It is related to MHC class I molecules, but its gene maps outside the MHC locus. The domain structure of ULBP3 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP3 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor. It functions as a stress-induced ligand for NKG2D receptor. In the normal hair follicle, ULBP3 is turned off. However, different studies reported its high level in alopecia areata (AA) . It is also expressed on some tumor cells and have been implicated in tumor surveillance. Recombinant human ULBP-3, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

NKG2D ligand 3, UL16 binding protein 3, N2DL-3, NKG2DL3, RAET1N, ALCAN-gamma, Retinoic acid early transcript 1N

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

1 mg/mL (determined by Absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS - PAGE

49.3kDa (430aa)

ATGP4009-10 µg, ATGP4009-20 µg, ATGP4009-50 µg, ATGP4009-100 µg, ATGP4009-250 µg, ATGP4009-500 µg, ATGP4009-1 mg, ATGP4009-10, ATGP4009-20, ATGP4009-50, ATGP4009-100, ATGP4009-250, ATGP4009-500, ATGP4009-1, ATGP4009-10 µg, ATGP4009-20 µg, ATGP4009-50 µg, ATGP4009-100 µg, ATGP4009-250 µg, ATGP4009-500 µg, ATGP4009-1 mg, ATGP4009-10, ATGP4009-20, ATGP4009-50, ATGP4009-100, ATGP4009-250, ATGP4009-500, ATGP4009-1

Moftah NH, et al, (2016) Arch Dermatol Res. 308:415-421.; ; Wirsching HG, et al, (2019) JCI Insight. 4:e128217.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_078794

Q9BZM4

Human

Ala

DAHSLWY NFTIIHLPRH GQQWCEVQSQ VDQKNFLSYD CGSDKVLSMG HLEEQLYATD AWGKQLEMLR EVGQRLRLEL ADTELEDFTP SGPLTLQVRM SCECEADGYI RGSWQFSFDG RKFLLFDSNN RKWTVVHAGA RRMKEKWEKD SGLTTFFKMV SMRDCKSWLR DFLMHRKKRL EPTAPPTMAP G