Recombinant humaan UMPS-eiwit

UMPS, also known as uridine 5'-monophosphate synthase, is a bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis. It is an indispensable component in this metabolic pathway and is a target for antimalarial and antitumor drugs. Its expression in colorectal carcinoma tissues is not correlated with the toxicities of 5-FU-based regimen, but It in the normal tissues can help predict the toxicities associated with 5-FU. Recombinant human UMPS, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Uridine 5'-monophosphate synthase, UMPS, OPRT

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

53 kDa (486aa)

UMPS, Uridine 5'-monophosphate synthase, UMPS, OPRT, ATGP3659-10 µg, ATGP3659-20 µg, ATGP3659-50 µg, ATGP3659-100 µg, ATGP3659-250 µg, ATGP3659-500 µg, ATGP3659-1 mg, ATGP3659-10, ATGP3659-20, ATGP3659-50, ATGP3659-100, ATGP3659-250, ATGP3659-500, ATGP3659-1

Zhang Y., et al. (2013) J Biol Chem. 288:34746-34754.; ; Dong Q., et al. (2012) Nan Fang Yi Ke Da Xue Xue Bao. 32:1179-1181.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol

Epigenomics (Transcription & Translation)

NP_000364.1

P11172

Human

Met1