Recombinant humaan VE-Cadherine/CDH5-eiwit

CDH5, as known as cadherin-5, is a member of the atypical/type 2 subgroup of Cadherin homophilic adhesion proteins. This protein plays a role in the formation, maturation and remodeling of the vascular wall. It is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. Also, this protein regulates or is regulated by VEGF R2, type 1 and type 2 TGF-beta receptors, and other endothelial junction proteins such as JAM-C, Claudin-5, and N-Cadherin. Recombinant human CDH5, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Cadherin-5, CDH5, 7B4, CD144, Vascular endothelial cadherin

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

91.5 kDa (810aa)

VE-Cadherin, Cadherin-5, CDH5, 7B4, CD144, ATGP3506-10 µg, ATGP3506-20 µg, ATGP3506-50 µg, ATGP3506-100 µg, ATGP3506-250 µg, ATGP3506-500 µg, ATGP3506-1 mg, ATGP3506-10, ATGP3506-20, ATGP3506-50, ATGP3506-100, ATGP3506-250, ATGP3506-500, ATGP3506-1

Yan Z., et al, (2016) Arterioscler. Thromb. Vasc. Biol. 36:339-349.; ; Timmerman I., et al, (2015) J. Cell. Sci. 128:3041-3054.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_001786.2

P33151

Human

Asn29