Recombinant humaan VEGF R2/KDR/Flk-1-eiwit

KDR, also known as vascular endothelial growth factor receptor 2, is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF) . There are three main subtypes of VEGFR (1, 2 and 3) . VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions like cancer. Also, this protein is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Recombinant human KDR protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Vascular endothelial growth factor receptor 2, KDR, CD309, FLK1, VEGFR, VEGFR2

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

110.5 kDa (987aa)

VEGF R2, KDR, Flk1, Vascular endothelial growth factor receptor 2, KDR, CD309, FLK1, VEGFR, VEGFR2, ATGP3627-10 µg, ATGP3627-20 µg, ATGP3627-50 µg, ATGP3627-100 µg, ATGP3627-250 µg, ATGP3627-500 µg, ATGP3627-1 mg, ATGP3627-10, ATGP3627-20, ATGP3627-50, ATGP3627-100, ATGP3627-250, ATGP3627-500, ATGP3627-1

Han KY., et al, (2009) Biochem Biophys Res Commun. 382:124-128.; ; Takyar S., et al, (2016) FASEB J. 30:1317-1327.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cardiovascular

NP_002244.1

P35968

Human

Ala

ASVGLPS VSLDLPRLSI QKDILTIKAN TTLQITCRGQ RDLDWLWPNN QSGSEQRVEV TECSDGLFCK TLTIPKVIGN DTGAYKCFYR ETDLASVIYV YVQDYRSPFI ASVSDQHGVV YITENKNKTV VIPCLGSISN LNVSLCARYP EKRFVPDGNR ISWDSKKGFT IPSYMISYAG MVFCEAKIND ESYQSIMYIV VVVGYRIYDV VLSPSHGIEL SVGEKLVLNC TARTELNVGI DFNWEYPSSK HQHKKLVNRD LKTQSGSEMK KFLSTLTIDG VTRSDQGLYT CAASSGLMTK KNSTFVRVHE KPFVAFGSGM ESLVEATVGE RVRIPAKYLG YPPPEIKWYK NGIPLESNHT IKAGHVLTIM EVSERDTGNY TVILTNPISK EKQSHVVSLV VYVPPQIGEK SLISPVDSYQ YGTTQTLTCT VYAIPPPHHI HWYWQLEEEC ANEPSQAVSV TNPYPCEEWR SVEDFQGGNK IEVNKNQFAL IEGKNKTVST LVIQAANVSA LYKCEAVNKV GRGERVISFH VTRGPEITLQ PDMQPTEQES VSLWCTADRS TFENLTWYKL GPQPLPIHVG ELPTPVCKNL DTLWKLNATM FSNSTNDILI MELKNASLQD QGDYVCLAQD RKTKKRHCVV RQLTVLERVA PTITGNLENQ TTSIGESIEV SCTASGNPPP QIMWFKDNET LVEDSGIVLK DGNRNLTIRR VRKEDEGLYT CQACSVLGCA KVEAFFIIEG AQEKTNLE