Recombinant humaan VSTM2L-eiwit

VSTM2L, also known as V-set and transmembrane domain containing 2, is a new modulator of HN neuroprotective activity. It colocalizes with HN in distinct brain areas as well as in primary cultured neurons, where it plays a role in the modulation of neuronal viability. When tested in HN neuroprotection bioassays, it acts as a strong antagonist of HN neuroprotective activity. This protein is the first example of a secreted antagonist of HN and may play a role in the modulation of HN biological functions. Recombinant human VSTM2L protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

V-set and transmembrane domain containing 2 like, dJ1118M15.2, C20orf102, V set and transmembrane domain containing 2 like

E.coli

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

22.6 kDa (205aa) confirmed by MALDI-TOF

VSTM2L, V-set and transmembrane domain containing 2 like, dJ1118M15.2, C20orf102, V set and transmembrane domain containing 2 like, ATGP1364-10 µg, ATGP1364-20 µg, ATGP1364-50 µg, ATGP1364-100 µg, ATGP1364-250 µg, ATGP1364-500 µg, ATGP1364-1 mg, ATGP1364-10, ATGP1364-20, ATGP1364-50, ATGP1364-100, ATGP1364-250, ATGP1364-500, ATGP1364-1

Collins S. et al. (2001) J. Clin. Neurosci. 8:387-397.; ; Rossini L. et al. (2011) FASEB J. 25:1983-2000

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT, 0.1mM PMSF

Other

AAH33818

Q96N03

Human

MGSSHHHHHH SSGLVPRGSH MGSHMTRPAG HAPWDNHVSG HALFTETPHD MTARTGEDVE MACSFRGSGS PSYSLEIQWW YVRSHRDWTD KQAWASNQLK ASQQEDAGKE ATKISVVKVV GSNISHKLRL SRVKPTDEGS YECRVIDFSD GKARHHKVKA YLRVQPGENS VLHLPEAPPA APAPPPPKPG KELRKRSVDQ EACSL