Recombinant humaan ZCCHC12-eiwit

ZCCHC12 belongs to the ZCCHC12 family and contains 1 CCHC-type zinc finger. This protein is a transcriptional coactivator in the bone morphogenetic protein (BMP) -signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. Recombinant human ZCCHC12 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Znc finger CCHC domain-containing protein 12, PNMA7A, SIZN, SIZN1

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

47.8 kDa (425aa)

ZCCHC12, Znc finger CCHC domain-containing protein 12, PNMA7A, SIZN, SIZN1, ATGP2704-10 µg, ATGP2704-20 µg, ATGP2704-50 µg, ATGP2704-100 µg, ATGP2704-250 µg, ATGP2704-500 µg, ATGP2704-1 mg, ATGP2704-10, ATGP2704-20, ATGP2704-50, ATGP2704-100, ATGP2704-250, ATGP2704-500, ATGP2704-1

Li, Q.L, et al. (2012) Med. Oncol. 29 (3), 1409-1417; ; Cho, G., et al. (2009) J. Biol. Chem. 284 (29), 19592-19600

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Epigenomics (Transcription & Translation)

NP_776159

Q6PEW1

Human

MGSSHHHHHH SSGLVPRGSH MGSMASIIAR VGNSRRLNAP LPPWAHSMLR SLGRSLGPIM ASMADRNMKL FSGRVVPAQG EETFENWLTQ VNGVLPDWNM SEEEKLKRLM KTLRGPAREV MRVLQATNPN LSVADFLRAM KLVFGESESS VTAHGKFFNT LQAQGEKASL YVIRLEVQLQ NAIQAGIIAE KDANRTRLQQ LLLGGELSRD LRLRLKDFLR MYANEQERLP NFLELIRMVR EEEDWDDAFI KRKRPKRSES MVERAVSPVA FQGSPPIVIG SADCNVIEID DTLDDSDEDV ILVESQDPPL PSWGAPPLRD RARPQDEVLV IDSPHNSRAQ FPSTSGGSGY KNNGPGEMRR ARKRKHTIRC SYCGEEGHSK ETCDNESDKA QVFENLIITL QELTHTEMER SRVAPGEYND FSEPL