Recombinant Human Retinoid X Receptor Alpha

Source : Escherichia Coli. RXRA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids (111-228) & having a molecular mass of 13.6 kDa. The retinoid X receptor (RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors (RAR), thyroid hormone receptors (TR), vitamin D receptors and peroxisome proliferators-activated receptors (PPAR) . The RXR family includes three different isoforms; RXR a, b, g . Human RXR a gene is localized on 9q34.9 and encodes two major isoforms (RXR a1, RXR a2) . The DNA binding domain of RXR (111-228aa) was purified by using conventional column chromatography techniques.

Retinoic acid receptor RXR-alpha||Retinoid X receptor alpha||Nuclear receptor subfamily 2 group B member 1||RXRA||NR2B1||FLJ00280||FLJ00318||FLJ16020||FLJ16733||MGC102720||RXR Alpha||RXR-a.

Greater than 95.0% as determined by SDS-PAGE.

The protein (1mg/mL) containing 20mM Tris-HCl pH7.5, 0.1M NaCl and 5mM Beta-Mercaptoethanol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.

MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE.