Recombinant Mouse Death Receptor 6/DR6/TNFRSF21/CD358 (C-Fc-6His)

Source : Human Cells; Tumor necrosis factor receptor superfamily member 21 (DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP) . N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) .

Tumor necrosis factor receptor superfamily member 21, Death receptor 6, Tnfrsf21, CD358, BM-018, DR6

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Ambient

Recombinant Mouse Death Receptor 6 is produced by our Mammalian expression system and the target gene encoding Gln42-His349 is expressed with a Fc, 6His tag at the C-terminus.