Recombinant muis B7-2/CD86 (C-His)

Source : Human 293 Cells; T-lymphocyte activation antigen CD86 (B7-2) is a type I membrane protein that belongs to the B7 family. CD86 is highly expressed on activated antigen presenting cells. CD86 plays an essential role for T-lymphocyte proliferation and interleukin-2 production through binding CD28 or CTLA-4. It is also involved in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Additionally, the CD86 participates innate immune responses by activating NF-kB-signaling pathway in macrophages. CD86 thus is predicted to be a promising candidate for immune therapy.

T-lymphocyte activation antigen CD86; Activation B7-2 antigen; Early T-cell costimulatorymolecule 1; ETC-1; CD86

Lyophilized from a 0.2 um filtered solution of PBS, pH7.4

Ambient

Recombinant Mouse T-lymphocyte Activation Antigen CD86 is produced by our Mammalian expression systemand the target gene encoding Val24-Lys244 is expressed with a 6His tag at the C-terminus.