Recombinant muis C1q R1/CD93 eiwit

CD93, also known as Complement component C1q receptor, is receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA) . This protein mediates the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. It may play a role in intercellular adhesion. This protein was expressed on (pre) plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. It is important for the maintenance of plasma cells in bone marrow niches. Recombinant mouse CD93, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Cd93, C1q/MBL/SPA receptor, C1qRp, Cell surface antigen AA4, Lymphocyte antigen 68, Ly-68

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

60.1 kDa (558aa)

C1q R1, CD93, Cd93, C1q/MBL/SPA receptor, C1qRp, Cell surface antigen AA4, Lymphocyte antigen 68, Ly-68, ATGP3231-10 µg, ATGP3231-20 µg, ATGP3231-50 µg, ATGP3231-100 µg, ATGP3231-250 µg, ATGP3231-500 µg, ATGP3231-1 mg, ATGP3231-10, ATGP3231-20, ATGP3231-50, ATGP3231-100, ATGP3231-250, ATGP3231-500, ATGP3231-1

Galvan MD., et al. (2012) J. Immunol. 188 (8) :3716-3723.; ; Greenlee-Wacker MC., et al. (2012) Curr Drug Targets 13 (3) :411-420.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_034870.1

O89103

Mouse