Recombinant muis CD200R1 eiwit

Cd200r1, also known cell surface glycoprotein CD200 receptor 1, is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. Its inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. Its signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, and inducible nitric oxide synthase in response to selected stimuli. Recombinant mouse Cd200r1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Human CD200 (CAT# ATGP3964) is coated at 1 µg/mL (100 ul/well) can bind Human CD200 R1. The ED50 range ≤ 1 µg/mL.

Cell surface glycoprotein CD200 receptor 1, Cd200r1, CD200R, Mox2r, OX2R, CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, CRTR2, MOX2 receptor

Baculovirus

Mouse

HIgG-His-Tag

SDS-PAGE, Bioactivity

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

Measured by its binding ability in a functional ELISA with Mouse CD200 (CAT# ATGP3964) . The ED50 range ≤ 1 µg/mL.

50.4 kDa (455aa)

CD200 R1, Cell surface glycoprotein CD200 receptor 1, Cd200r1, CD200R, Mox2r, OX2R, ATGP3457-10 µg, ATGP3457-20 µg, ATGP3457-50 µg, ATGP3457-100 µg, ATGP3457-250 µg, ATGP3457-500 µg, ATGP3457-1 mg, ATGP3457-10, ATGP3457-20, ATGP3457-50, ATGP3457-100, ATGP3457-250, ATGP3457-500, ATGP3457-1

Vaine CA., et al. (2014) Adv Immunol. 121:191-211.; ; Horie S., et al. (2013) Sci Rep. 3:3072.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_067300

Q9ES57

Mouse

Ala

TDKNQTT QNNSSSPLTQ VNTTVSVQIG TKALLCCFSI PLTKAVLITW IIKLRGLPSC TIAYKVDTKT NETSCLGRNI TWASTPDHSP ELQISAVTLQ HEGTYTCETV TPEGNFEKNY DLQVLVPPEV TYFPEKNRSA VCEAMAGKPA AQISWSPDGD CVTTSESHSN GTVTVRSTCH WEQNNVSDVS CIVSHLTGNQ SLSIELSRGG NQSLRP