Recombinant muis DKK1 eiwit (C-His tag)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-coding gene that acts from the anterior visceral endoderm. The dickkopf protein encoded by DKK1 is an antagonist of the Wnt/β-catenin signalling pathway that acts by isolating the LRP6 co-receptor so that it cannot aid in activating the WNT signaling pathway. DKK1 was also demonstrated to antagonize the Wnt/β-catenin pathway via a reduction in β-catenin and an increase in OCT4 expression. This inhibition plays a key role in heart, head and forelimb development during anterior morphogenesis of the embryo.
Greater than 95% by SDS-PAGE
Lyophilized
0.2 μm filtered PBS, pH7.4
-70°C
Beschrijving
Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.This gene encodes a protein that is a member of the dickkopf family. It is a
Specificaties
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