Recombinant muis EphB4-eiwit

Ephb4, also known as ephrin type-B receptor 4 isoform b, is a member of the Eph receptor tyrosine kinase family shown to act in neuronal guidance and mediate venal/arterial separation. Ephb4 provides survival advantage to squamous cell carcinoma of the head and neck. It has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Recombinant mouse Ephb4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

EPH receptor B4, Ephrin type-B receptor 4, Developmental kinase 2, mDK-2, Hepatoma transmembrane kinase, Tyrosine kinase MYK-1, Htk, Mdk2, Tyro11

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

58.7 kDa (532aa)

EphB4, Ephrin type-B receptor 4 isoform b, Eph receptor B4, AI042935, Htk, MDK2, Myk1, Tyro11, Ephb4, EPHB4_HUMAN, Ephrin receptor, EphB4, Ephrin type-B receptor 4, Hepatoma Transmembrane Kinase, HTK, MYK 1, MYK1, TYRO 11, TYRO11, Tyrosine-protein kinase receptor HTK, Tyrosine-protein kinase TYRO11, ATGP3415-10 µg, ATGP3415-20 µg, ATGP3415-50 µg, ATGP3415-100 µg, ATGP3415-250 µg, ATGP3415-500 µg, ATGP3415-1 mg, ATGP3415-10, ATGP3415-20, ATGP3415-50, ATGP3415-100, ATGP3415-250, ATGP3415-500, ATGP3415-1

Xiao Z. et al., (2012) Cancer Biol Ther. 13:630-637.; ; Masood R. et al., (2006) Int J Cancer. 119:1236-1248.; ; Dopeso H. et al., (2009) Cancer Res. 69:7430-7438.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cardiovascular

NP_034274

P54761

Mouse

Leu16