Recombinant muis FKBP12/FKBP1A eiwit

Fkbp1a also known as peptidyl-prolyl cis-trans isomerase FKBP1A belongs to the immunophilin protein family, which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Fkbp1a also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1, 4, 5-trisphosphate receptor. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. Recombinant mouse Fkbp1a, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Peptidyl-prolyl cis-trans isomerase FKBP1A, PPIase FKBP1A, 12 kDa FK506-binding protein (12 kDa FKBP; FKBP-12), Calstabin-1, FK506-binding protein 1A (FKBP-1A), Immunophilin FKBP12, Rotamase

E.coli

Mouse

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

14.4 kDa (132aa) confirmed by MALDI-TOF

Fkbp1a, Peptidyl-prolyl cis-trans isomerase FKBP1A, 12kDa, Fkbp, Fkbp1, FKBP12, FKBP12-T1, FKBP12-T2, mFKBP1, mFKBP12, ATGP3084-10 µg, ATGP3084-20 µg, ATGP3084-50 µg, ATGP3084-100 µg, ATGP3084-250 µg, ATGP3084-500 µg, ATGP3084-1 mg, ATGP3084-10, ATGP3084-20, ATGP3084-50, ATGP3084-100, ATGP3084-250, ATGP3084-500, ATGP3084-1

Chen H., et al. (2013) Development 140 (9), 1946-1957

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT

Immunology

NP_032045

P26883

Mouse

MGSSHHHHHH SSGLVPRGSH MGSHMGVQVE TISPGDGRTF PKRGQTCVVH YTGMLEDGKK FDSSRDRNKP FKFTLGKQEV IRGWEEGVAQ MSVGQRAKLI ISSDYAYGAT GHPGIIPPHA TLVFDVELLK LE