Recombinant muis GP130/IL6ST eiwit

IL6st, also known as interleukin-6 receptor subunit beta, is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion. Recombinant mouse IL6st, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Interleukin-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha, CD130

Baculovirus

Mouse

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

67.7 kDa (603aa)

Oncostatin-M receptor subunit alpha, Oncostatin M receptor subunit alpha, Membrane glycoprotein 130, Interleukin-6 signal transducer, Interleukin-6 receptor subunit beta, Interleukin 6 signal transducer, Interleukin 6 receptor subunit beta, Il6st, IL-6R-beta, IL-6RB, IL-6R subunit beta, IL6R subunit beta, IL-6R beta, IL-6R B, IL6R b, IL 6RB, IL 6R subunit beta, IL 6R beta, IL 6R B, GP130, GP 130, D13Ertd699e, CD130, CD 130, BB405851, AA389424, 5133400A03Rik, ATGP3201-10 µg, ATGP3201-20 µg, ATGP3201-50 µg, ATGP3201-100 µg, ATGP3201-250 µg, ATGP3201-500 µg, ATGP3201-1 mg, ATGP3201-010, ATGP3201-020, ATGP3201-050, ATGP3201-100, ATGP3201-250, ATGP3201-500, ATGP3201-01M

Saito M., et al. (1992) J Immunol. 148: 4066-4071.; ; Murakami M., et al. (1993) Science. 260:1808-1810.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Apoptosis

NP_034690

Q00560

Mouse

QLLEPCGYIY PEFPVVQRGS NFTAICVLKE ACLQHYYVNA SYIVWKTNHA AVPREQVTVI NRTTSSVTFT DVVLPSVQLT CNILSFGQIE QNVYGVTMLS GFPPDKPTNL TCIVNEGKNM LCQWDPGRET YLETNYTLKS EWATEKFPDC QSKHGTSCMV SYMPTYYVNI EVWVEAENAL GKVSSESINF DPVDKVKPTP PYNLSVTNSE ELSSILKLSW VSSGLGGLLD LKSDIQYRTK DASTWIQVPL EDTMSPRTSF TVQDLKPFTE YVFRIRSIKD SGKGYWSDWS EEASGTTYED RPSRPPSFWY KTNPSHGQEY RSVRLIWKAL PLSEANGKIL DYEVILTQSK SVSQTYTVTG TELTVNLTND RYVASLAARN KVGKSAAAVL TIPSPHVTAA YSVVNLKAFP KDNLLWVEWT PPPKPVSKYI LEWCVLSENA PCVEDWQQED ATVNRTHLRG RLLESKCYQI TVTPVFATGP GGSESLKAYL KQAAPARGPT VRTKKVGKNE AVLAWDQIPV DDQNGFIRNY SISYRTSVGK EMVVHVDSSH TEYTLSSLSS DTLYMVRMAA YTDEGGKDGP EFTFTTPKFA QGEIELEHHH HHH