Recombinant muis Histone Deacetylase 8/HDAC8 eiwit

Hdac8, also known as histone deacetylase 8 isoform 1, is a member of the class I Histone Deacetylases. Its specific inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. It expressed in the renal epithelial cells of the mouse kidney. Its activity contributes to renal protection and functional recovery and is required for renal regeneration after AKI. Recombinant mouse Hdac8, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Histone deacetylase 8 isoform 1, Hdac8, 2610007D20Rik, HD8, Protein deacetylase HDAC8, Protein decrotonylase HDAC8

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

42.5 kDa (383aa)

Hdac8, Histone deacetylase 8 isoform 1, Hdac8, 2610007D20Rik, ATGP3515-10 µg, ATGP3515-20 µg, ATGP3515-50 µg, ATGP3515-100 µg, ATGP3515-250 µg, ATGP3515-500 µg, ATGP3515-1 mg, ATGP3515-10, ATGP3515-20, ATGP3515-50, ATGP3515-100, ATGP3515-250, ATGP3515-500, ATGP3515-1

Li S., et al. (2015) J Biol Chem. 290:2368-2378.; ; Tang J., et al. (2014) Am J Physiol Renal Physiol. 307:F303-316.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Epigenomics (Transcription & Translation)

NP_081658

Q8VH37

Mouse

Met1