Recombinant muis HVEM/TNFRSF14 eiwit

HVEM/TNFRSF14, also known as tumor necrosis factor receptor superfamily member 14, is a member of TNF receptor superfamily. This protein was originally known as herpesvirus entry mediator A (HveA) ; HveB and HveC are structurally unrelated proteins of the immunoglobulin superfamily. The cytoplasmic region of this receptor was found to bind to several TNF receptor associated factor (TRAF) family members, which may mediate the signal transduction pathways that activate the immune response. It promotes and inhibits T cell activity. This protein signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. It participates in cell to cell contact signaling between antigen presenting cells and lymphocytes. This protein downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. Recombinant mouse HVEM/TNFRSF14, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A, HveA, Tumor necrosis factor receptor-like 2, TR2, CD270, HVEM, ATAR, LIGHTR

Baculovirus

Mouse

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

45.3 kDa (407aa)

HVEM, TNFRSF14, ATGP3916-10 µg, ATGP3916-20 µg, ATGP3916-50 µg, ATGP3916-100 µg, ATGP3916-250 µg, ATGP3916-500 µg, ATGP3916-1 mg, ATGP3916-10, ATGP3916-20, ATGP3916-50, ATGP3916-100, ATGP3916-250, ATGP3916-500, ATGP3916-1

Choi EK., et al. (2013) J Endocrinol. 220:25-33.; ; Kotsiou E., et al. (2018) Blood. 128:72-81.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_849262.1

Q80WM9

Mouse

Gln39