Recombinant muis IGFBP-6 eiwit

Igfbp6, also known as insulin-like growth factor-binding protein 6, binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. It is a cysteine-rich protein with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. It plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity. Recombinant mouse Igfbp6, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Insulin-like growth factor-binding protein 6, Igfbp6, IGFBP-6, IBP 6, IBP-6, IBP6, IBP6_HUMAN, IGF binding protein 6, IGF-binding protein 6, IGFBP 6, IGFBP-6, IGFBP6, Insulin like growth factor binding protein 6, Insulin-like growth factor-binding protein 6

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

23.7 kDa (221aa)

IGFBP6, Insulin-like growth factor-binding protein 6 , Igfbp6, IGFBP-6, IBP 6, IBP-6, IBP6, IBP6_HUMANIGF binding protein 6, IGF-binding protein 6IGFBP 6, IGFBP-6, IGFBP6, Insulin like growth factor binding protein 6, Insulin-like growth factor-binding protein 6, ATGP3411-10 µg, ATGP3411-20 µg, ATGP3411-50 µg, ATGP3411-100 µg, ATGP3411-250 µg, ATGP3411-500 µg, ATGP3411-1 mg, ATGP3411-10, ATGP3411-20, ATGP3411-50, ATGP3411-100, ATGP3411-250, ATGP3411-500, ATGP3411-1

Shalamanova L., et al. (2008) Mol Cell Endocrinol. 295:18-23.; ; Bach LA., et al. (1999) Horm Metab Res. 31:226-234.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 40% glycerol

Signal Transduction

NP_032370

P47880

Mouse

Ala26

ALAGCPGCGA GMQTGCRGGC VEEEDAGSPA DGCTEAGGCL RREGQPCGVY SPKCAPGLQC QPRENEEAPL RALLIGQGRC QRARGPSEET TKESKPQGGA SRSRDTNHRD RQKNPRTSAA PIRPNPVQDS EMGPCRRHLD SVLQQLQTEV FRGGARGLYV PNCDLRGFYR KQQCRSSQGN RRGPCWCVDP MGQPLPVSPD GQGSTQCSAR SSGLEHHHHH H