Recombinant muis LRIG1-eiwit

LRIG1, also known as leucine-rich repeats and immunoglobulin-like domains 1 is a pan-negative regulator of the epidermal growth factor receptor (EGFR) signaling pathway. In studies with ErbB family members and Met kinase, LRIG regulates signaling by increasing ubiquitination and lysosomal degradation of the receptors. It functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases. This protein expression, which is often dysregulated in human cancers, is a prognostic indicator of cancer development and relapse. Recombinant mouse LRIG1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1, D6Bwg0781e, Img

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

84.8kDa (770aa)

, ATGP3937-10 µg, ATGP3937-20 µg, ATGP3937-50 µg, ATGP3937-100 µg, ATGP3937-250 µg, ATGP3937-500 µg, ATGP3937-1 mg, ATGP3937-10, ATGP3937-20, ATGP3937-50, ATGP3937-100, ATGP3937-250, ATGP3937-500, ATGP3937-1

JonasNilsson., et al, (2001) Biochem Biophys Res Commun. 284:1155–1161.; ; Gal Gur., et al, (2004) EMBO J. 23:3270–3281.; ; Xi Zhang., et al, (2015) Cell Stress Chaperones. 20:631-641.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cancer

NP_032403

P70193

Mouse