Recombinant muis LRPAP eiwit

Lrpap1 also known as Alpha-2-macroglobulin receptor-associated protein. The alpha-2-macroglobulin receptor-associated protein (RAP) is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. Lrpap1 acts to inhibit the binding of all know ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. Lrpap1 may be under the regulatory control of calmodulin, since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II. Recombinant mouse Lspap1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alpha-2-macroglobulin receptor-associated protein, Alpha 2 macroglobulin receptor associated protein, AA617339, AI790446, AU042172, C77774, HBP44, RAP

E.coli

Mouse

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

> 90% by SDS-PAGE

41.4 kDa (355aa) confirmed by MALDI-TOF

LRPAP, Alpha-2-macroglobulin receptor-associated protein, Alpha 2 macroglobulin receptor associated protein, AA617339, AI790446, AU042172, C77774, HBP44, RAP, ATGP3133-10 µg, ATGP3133-20 µg, ATGP3133-50 µg, ATGP3133-100 µg, ATGP3133-250 µg, ATGP3133-500 µg, ATGP3133-1 mg, ATGP3133-10, ATGP3133-20, ATGP3133-50, ATGP3133-100, ATGP3133-250, ATGP3133-500, ATGP3133-1

Strickland D.K., et al. (1991) J. Biol. Chem. 266:13364-13369. ; ; Van Leuven F., et al. (1998) Genomics 52:145-151.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Metabolism

NP_038615

P55302

Mouse

QPIAGHG GKYSREKNEP EMAAKRESGE EFRMEKLNQL WEKAKRLHLS PVRLAELHSD LKIQERDELN WKKLKVEGLD KDGEKEAKLI HNLNVILARY GLDGRKDAQM VHSNALNEDT QDELGDPRLE KLWHKAKTSG KFSSEELDKL WREFLHYKEK IQEYNVLLDT LSRAEEGYEN LLSPSDMAHI KSDTLISKHS ELKDRLRSIN QGLDRLRKVS HQGYGSTTEF EEPRVIDLWD LAQSANFTEK ELESFREELK HFEAKIEKHN HYQKQLEISH QKLKHVESIG DPEHISRNKE KYVLLEEKTK ELGYKVKKHL QDLSSRVSRA RHNEL