Recombinant muis Lumican eiwit

Lumican, also known as Lum, is a proteoglycan Class II member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. It is a major component of the corna, demal, and muscle connective tissues. This protein has a negatively-charged N-terminal domain containing sulfated tyrosine and disulfide bonds and ten tandem leucine-rich that repeats allowing it to bind to other extracellular components such as collagen. Lum is the major keratin sulfate proteoglycan of the cornea and is distributed in interstitial collagenous matrices throughout the body. Also, it plays a role as definitive link between a necessity for this protein in the development of a highly organized collagenous matrix and corneal transparency. Recombinant Mouse Lumican, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Lum, Ldc, SLRR2D, Lumican, Keratan sulfate proteoglycan lumican, KSPG lumican

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

37.5 kDa (328aa)

Lumican, ATGP3871-10 µg, ATGP3871-20 µg, ATGP3871-50 µg, ATGP3871-100 µg, ATGP3871-250 µg, ATGP3871-500 µg, ATGP3871-1 mg, ATGP3871-10, ATGP3871-20, ATGP3871-50, ATGP3871-100, ATGP3871-250, ATGP3871-500, ATGP3871-1

Castillo EF., et al, (2016) Eur. J. Immunol. 46:2852-2861.; ; Ying S., et al, (1997) J. Biol. Chem. 272:30306-30313.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Cancer

NP_032550

P51885

Mouse

Gln19