Recombinant muis Mer eiwit

Mer, also known as Tyrosine-protein kinase Mer, is one of the receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm. It regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells. This protein plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Mutations in this protein have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP) . Recombinant mouse Mer, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Mertk, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, Eyk, Mer, nmf12, Nyk, Tyrosine-protein kinase Mer

Baculovirus

Mouse

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

79.2 kDa (718aa)

Mer, ATGP3906-10 µg, ATGP3906-20 µg, ATGP3906-50 µg, ATGP3906-100 µg, ATGP3906-250 µg, ATGP3906-500 µg, ATGP3906-1 mg, ATGP3906-10, ATGP3906-20, ATGP3906-50, ATGP3906-100, ATGP3906-250, ATGP3906-500, ATGP3906-1

Grabiec AM., et al. (2018) Eur J Immunol. 48:855-860.; ; McHenry CL., et al. (2004) Invest Ophthalmol Vis Sci. 45:1456-1463.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_032613

Q60805

Mouse

Gly19