Recombinant muis MESDC2-eiwit

MESDC2 also known as LDLR chaperone MESD. This protein is specialized chaperone for low-density lipoprotein receptor-related protein 5 and LRP6. MESDC2 binds to mature LRP6 on the cell surface and blocks the binding of Wnt antagonist Dickkopf-1 to LRP6. Furthermore, MESDC2 plays an essential role in NMJ formation by promoting Lrp4 maturation. Recombinant mouse MESDC2, fused to His-tag at N-terminus was expressed in E. coli and purified by using conventional chromatography techniques.

2210015O11Rik, AW537813, mesd, mKIAA0081, msd

E.coli

Mouse

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

> 90% by SDS-PAGE

24.4 kDa (218aa)

MESDC2, 2210015O11Rik, AW537813, mesd, mKIAA0081, msd, ATGP3257-10 µg, ATGP3257-20 µg, ATGP3257-50 µg, ATGP3257-100 µg, ATGP3257-250 µg, ATGP3257-500 µg, ATGP3257-1 mg, ATGP3257-10, ATGP3257-20, ATGP3257-50, ATGP3257-100, ATGP3257-250, ATGP3257-500, ATGP3257-1

Lu W., et al. (2010) Biochemistry. 49 (22) : 4635-43.; ; Hoshi T., et al. (2013) FEBS Lett. 587 (23) : 3749-54.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_075892

Q9ERE7

Mouse

MGSSHHHHHH SSGLVPRGSH MGSADTPGEA TPPPRKKKDI RDYNDADMAR LLEQWEKDDD IEEGDLPEHK RPSAPIDFSK LDPGKPESIL KMTKKGKTLM MFVTVSGNPT EKETEEITSL WQGSLFNANY DVQRFIVGSD RAIFMLRDGS YAWEIKDFLV SQDRCAEVTL EGQMYPGKGG GSKEKNKTKP EKAKKKEGDP KPRASKEDNR AGSRREDL