Recombinant muis OX40/TNFRSF4-eiwit

TNFRSF4, also known as CD134, is a member of the TNFR-superfamily of receptors. This protein is a receptor for TNFSF4/OX40L/GP34 and a costimulatory molecule implicated in long-term T-cell immunity. OX40-OX40L interactions regulate antigen-specific T-cell expansion and survival, cytokine production. It also modulates cytokine receptor signalling. Therefore the interaction between TNFRSF4 and CD40L plays a key role in the development of multiple imflammatry and autoimmune disease. It has been implicated in the pathologic cytokine storm associated with certain viral infections, including the H5N1 bird flu. Recombinant mouse OX40/TNFRSF4 , fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Tumor necrosis factor receptor superfamily member 4, TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor

HEK293

Mouse

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by Absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

48.6kDa (435aa)

, ATGP3971-10 µg, ATGP3971-20 µg, ATGP3971-50 µg, ATGP3971-100 µg, ATGP3971-250 µg, ATGP3971-500 µg, ATGP3971-1 mg, ATGP3971-10, ATGP3971-20, ATGP3971-50, ATGP3971-100, ATGP3971-250, ATGP3971-500, ATGP3971-1

Schreiber TH, et al, (2012) J Immunol. 189:3311-3318.; ; Webb GJ, et al, (2016) Clin Rev Allergy Immunol. 50:312-332.; ; Zhou B, et al, (2020) Transplant Proc. 52:398-405.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_035789.1

P47741

Mouse

Asp

VTARRL NCVKHTYPSG HKCCRECQPG HGMVSRCDHT RDTLCHPCET GFYNEAVNYD TCKQCTQCNH RSGSELKQNC TPTQDTVCRC RPGTQPRQDS GYKLGVDCVP CPPGHFSPGN NQACKPWTNC TLSGKQTRHP ASDSLDAVCE DRSLLATLLW ETQRPTFRPT TVQSTTVWPR TSELPSPPTL VTPEGP