Recombinant muis SDF-1/CXCL12 eiwit

Cxcl12 also known as stromal cell-derived factor 1 isoform alpha. This protein acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. This protein inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Cxcl12 protein plays a protective role after myocardial infarction. It induces down-regulation and internalization of ACKR3 expressed in various cells. Recombinant mouse Cxcl12, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques

Stromal cell-derived factor 1 isoform alpha, Stromal cell-derived factor 1, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1, TPAR1, C-X-C motif chemokine 12, Pre-B cell growth-stimulating factor, PBSF, Thymic lymphoma cell-stimulating factor, TLSF, Scyb12, Sdf1, SDF-1, Sdf1a, Sdf1b

E.coli

Mouse

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

> 95% by SDS-PAGE

10.4 kDa (91aa) confirmed by MALDI-TOF

CXCL12, SDF1, Stromal cell-derived factor 1 isoform alpha, Pbsf, Scyb12, Sdf1, Tlsf, Tpar1, ATGP3159-10 µg, ATGP3159-20 µg, ATGP3159-50 µg, ATGP3159-100 µg, ATGP3159-250 µg, ATGP3159-500 µg, ATGP3159-1 mg, ATGP3159-10, ATGP3159-20, ATGP3159-50, ATGP3159-100, ATGP3159-250, ATGP3159-500, ATGP3159-1

Beaulande M., et al. (1998) Nucleic Acids. 26 (2) :521-4; ; Chen T., et al. (2015) Am J Transplant. 15 (3) :618-27

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Hormones & Cytokines

NP_068350.1

P40224

Mouse

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