Recombinant muis Serpin E2/PN1 eiwit

Serpine2, as known as glia-derived nexin, is a member of the Serpin superfamily of the serine protease inhibitors. This protein is a potent inhibitor of thrombin, plasmin and plasminogen activators. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuron-like cells. Also, it is over expression in mice leads to progressive neuronal and motor dysfunction in these animals. Recombinant mouse Serpine2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques

Glia-derived nexin, Serpnie2, B230326M24Rik, PAI-1, PI-7, PI7, PN-1, Spi4, GDN, GDN_HUMAN, GDNPF, Glia derived nexin, Glia-derived nexin, Glial derived neurite promoting factor, P17, Peptidase inhibitor 7, Pi-7, Plasminogen activator inhibitor type 1 member 2, PN-1, PN1, PNI, Protease inhibitor 7, Protease nexin 1, Protease nexin I, Serpin E2, Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2, SERPINE 2, Serpine2

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

42.9 kDa (386aa)

Serpin E2, PN1, Glia-derived nexin , Serpnie2, B230326M24Rik, PAI-1, PI-7, PI7, PN-1, Spi4, GDN, GDN_HUMAN, GDNPF, Glia derived nexin, Glia-derived nexin, Glial derived neurite promoting factor, P17, Peptidase inhibitor 7Pi-7, Plasminogen activator inhibitor type 1, member 2PN-1, PN1, PNI, Protease inhibitor 7, Protease nexin 1, Protease nexin I, Serpin E2, Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2, SERPINE 2, Serpine2, ATGP3401-10 µg, ATGP3401-20 µg, ATGP3401-50 µg, ATGP3401-100 µg, ATGP3401-250 µg, ATGP3401-500 µg, ATGP3401-1 mg, ATGP3401-10, ATGP3401-20, ATGP3401-50, ATGP3401-100, ATGP3401-250, ATGP3401-500, ATGP3401-1

Lu CH., et al. (2013) PLoS ONE 8:E74602.; ; McKee CM., et al. (2012) J. Clin. Invest. 122:4025-4036.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_033281

Q07235

Mouse

Ser20