Recombinant muis TIE2/TEC eiwit

TEK, also known as angiopoietin-1 receptor isoform 2, is cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4. It regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton. This protein effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Recombinant mouse TEK, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

TEK, TEK receptor tyrosine kinase, VMCM, venous malformations, multiple cutaneous and mucosal, TEK tyrosine kinase, endothelial, TIE2, TIE-2, VMCM1, CD202b, angiopoietin-1 receptor, Hyk, AA517024, STK1, p140 TEK

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

81.6 kDa (730aa)

Angiopoietin1 receptor, Tek, Hyk, Tie-2, Tie2, CD202b, AA517024, STK1, ATGP3190-10 µg, ATGP3190-20 µg, ATGP3190-50 µg, ATGP3190-100 µg, ATGP3190-250 µg, ATGP3190-500 µg, ATGP3190-1 mg, ATGP3190-10, ATGP3190-20, ATGP3190-50, ATGP3190-100, ATGP3190-250, ATGP3190-500, ATGP3190-1

Horita K et al., (1992) Biochem. Biophys. Res. Commun. 189 (3) :1747-1753.; ; Dumont DJ et al., (1992) Oncogene 7 (8) :1471-1480.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cardiovascular

NP_001277478

Q02858

Mouse