Recombinant muis TSLP-eiwit

TSLP, also known as thymic stromal lymphopoietin, is a protein belonging to the cytokine family. This protein plays an important role in the maturation of T cell populations through activation of antigen presenting cells. It is an interleukin 7-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs) . It is expressed by non-hematopoietic cells such as fibroblasts, epithelial cells and different types of stromal or stromal-like cells, and is important in allergic inflammation. It signals through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor CRLF2 and the IL-7R alpha chain. After binding STAT5 phosphorylation is induced resulting in the expression of upstream transcription factors. Also, expression of TSLP is linked to many disease states including asthma, inflammatory arthritis, atopic dermatitis, eczema, eosinophilic esophagitis and other allergic states. But the factors are not clearly defined. Recombinant Mouse TSLP, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Thymic stromal lymphopoietin, Thymic stroma-derived lymphopoietin, Tslp

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

15kDa (130aa)

TSLP, ATGP3879-10 µg, ATGP3879-20 µg, ATGP3879-50 µg, ATGP3879-100 µg, ATGP3879-250 µg, ATGP3879-500 µg, ATGP3879-1 mg, ATGP3879-10, ATGP3879-20, ATGP3879-50, ATGP3879-100, ATGP3879-250, ATGP3879-500, ATGP3879-1

Sims JE., et al, (2000) J. Exp. Med. 192:671-680.; ; Pandey A., et al, (2000) Nautre Immunol. 1:59.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_067342.1

Q9JIE6

Mouse

Ala

YNFSNCN FTSITKIYCN IIFHDLTGDL KGAKFEQIED CESKPACLLK IEYYTLNPIP GCPSLPDKTF ARRTREALND HCPGYPETER NDGTQEMAQE VQNICLNQTS QILRLWYSFM QSPE