Recombinant muis Tyro3/Dtk-eiwit

Tyro3, also known as tyrosine-protein kinase receptor TYRO3 isoform A, is one of the receptor tyrosinekinase subfamily. It transduces signals from the extracellular matrix into the cytoplasm by binding to severalligands including TULP1 or GAS6. This protein regulates many physiological processes including cellsurvival, migration and differentiation. It activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. This protein plays a role invarious processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeletonreorganization. Recombinant mouse Tyro3, fused to hIgG-His-tag at C-terminus, was expressed in insect celland purified by using conventional chromatography techniques.

Tyro3, AI323366, Brt, Dtk, Etk-2, etk2/tyro3, Rse, Sky, Tif, tk19-1, Tyrosine-protein kinasereceptor TYRO3, Etk2/tyro3, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase TIF

Baculovirus

Mouse

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

68.9 kDa (628aa)

Tyro3, Dtk, ATGP3911-10 µg, ATGP3911-20 µg, ATGP3911-50 µg, ATGP3911-100 µg, ATGP3911-250 µg, ATGP3911-500 µg, ATGP3911-1 mg, ATGP3911-10, ATGP3911-20, ATGP3911-50, ATGP3911-100, ATGP3911-250, ATGP3911-500, ATGP3911-1

Shao H., et al. (2017) Biochem Biophys Res Commun. 490:1074-1079.; ; Blades F., et al. (2018) Glia. 66:2209-2220.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_062265

P55144

Mouse

Ala31