Recombinant NF-kB2 p100/p52 Monoklonale antilichamen

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function.

NF-kB2 p100/p52

Q00653

Human; Rat; Mouse

Recombinant human NF-kB2 p100/p52 fragment

CVID; H2TF; NFKB; NF-kB; p49/p; LYT; CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100; p49/p100; p52; NFKB2; p105

A538

Unconjugated

WB; IHC; IF

Signal Transduction; Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:1000-1:5000; IHC 1:50-1:100; IF 1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/UTPkihxa

97 kDa

120 kDa

IgG, κ