Recombinant Rab8A Monoklonale Antilichaam

The Rab8 GTPase is a member of the Ras superfamily that functions in protein transport and membrane restructuring. RAB8 has two isoforms, RAB8A and RAB8B, that share 40% amino acid identity in the C-terminal variable region. RAB8 activity is regulated by specific guanine nucleotide exchange factors (GEFs), that mediate GTP loading, and GTPase activating proteins (GAPs) that convert them into the inactive GDP-bound form. RAB8 participates in recycling of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors to the dendritic spine surface as well as in the intracellular transport of the metabotropic glutamate receptor type 1 in neuronal cells. Rab8 is activated at the base of the cilium by its guanine nucleotide exchanger Rabin8.

Rab8A

P61006

Human; African green monkey

Recombinant human Rab8A fragment

RAB; RAB8A; MEL; RAB8; AA409338; Mel transforming oncogene; Mel transforming oncogene (derived from cell line NK14) ; Mel transforming oncogene (derived from cell line NK14) RAB8 homolog; Mel transforming oncogene (RAB8 homolog) ; MGC124948; Oncogene c mel; Oncogene c-mel; RAB8A member RAS oncogene family; Ras associated protein RAB8; Ras related protein Rab 8A; Ras-related protein Rab-8A

A639

Unconjugated

WB; IHC

Signal Transduction

Protein A purified

1 mg/mL

WB 1:1000-1:2000; IHC 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/iJiudiVw

24 kDa

24 kDa

IgG, κ