Recombinant Raf-1 Monoklonale Antilichaam

This gene is the cellular homolog of viral raf gene (v-raf) . The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Raf-1

P04049

Human; Mouse; Rat

Recombinant Human Raf-1 protein

CMD1NN; CRAF; NS5; Raf-1; c-Raf; RAF1; RAF; Proto-oncogene c-RAF (cRaf) ; RAF proto-oncogene serine/threonine-protein kinase

1F16

Unconjugated

WB

Signal Transduction; Cell Biology; Cancer; Metabolism

Protein A

0.2 mg/mL

WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/Q9uIxh9m

73 kDa

73 kDa

IgG, κ