Recombinant rat DYRK1A-eiwit

DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidin6e repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. Recombinant rat DYRK1A protein, fused to His-tag at N-terminus, was expressed in E. coli.

Dual-specificity tyrosine- (Y) -phosphorylation regulated kinase 1A, Dual Specificity Yak1-related kinase, Dyrk; PSK47

E.coli

Rat

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 80% by SDS-PAGE

39.4 kDa (343aa)

DYRK1A, Dual-specificity tyrosine- (Y) -phosphorylation regulated kinase 1A, Dual Specificity Yak1-related kinase, Dyrk; PSK47, ATGP2720-10 µg, ATGP2720-20 µg, ATGP2720-50 µg, ATGP2720-100 µg, ATGP2720-250 µg, ATGP2720-500 µg, ATGP2720-1 mg, ATGP2720-10, ATGP2720-20, ATGP2720-50, ATGP2720-100, ATGP2720-250, ATGP2720-500, ATGP2720-1

Pryor A., Tung L. et al. (2004) . Nucleic Acids Res. 32:1857-1865

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Neuroscience

NP_036923

Q63470

Rat

YEIDSLIG KGSFGQVVKA YDRVEQEWVA IKIIKNKKAF LNQAQIEVRL LELMNKHDTE MKYYIVHLKR HFMFRNHLCL VFEMLSYNLY DLLRNTNFRG VSLNLTRKFA QQMCTALLFL ATPELSIIHC DLKPENILLC NPKRSAIKIV DFGSSCQLGQ RIYQYIQSRF YRSPEVLLGM PYDLAIDMWS LGCILVEMHT GEPLFSGANE VDQMNKIVEV LGIPPAHILD QAPKARKFFE KLPDGTWSLK KTKDGKREYK PPGTRKLHNI LGVETGGPGG RRAGESGHTV ADYLKFKDLI LRMLDYDPKT RIQPYYALQH SFF