Recombinant Shh Monoklonale Antilichaam

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.

Shh

Q15465

Human; Mouse; Rat

Recombinant Human Shh protein

HLP; HPE; MCOPCB; HHG1; HHG-1; HLP3; HPE3; MCOPCB5; SMMCI; Sonic hedgehog; Sonic Hedgehog Protein; TPT; TPTPS; SHH; HHG 1; HLP 3; Holoprosencephaly 3; HPE 3; SMMC I; Sonic Hedgehog (Drosophila) homolog; Sonic hedgehog homolog; sonic hedgehog homolog (Drosophila) ; Sonic hedgehog protein C-product; Shh

2D9

Unconjugated

IHC

Epigenetics and Nuclear Signaling; Stem Cells; Cancer; Developmental Biology; Metabolism

Protein A

0.2 mg/mL

IHC 1:200-1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/xM0z9kyj

IgG, κ