Recombinant SLC25A12 Monoklonale antilichamen

The calcium-binding mitochondrial carrier protein (SLC25A12), also named as ARALAR or AGC1, is an aspartate-glutamate exchange protein responsible for transporting mitochondrial aspartate across the mitochondrial inner membrane in exchange for cytosolic glutamate. SLC25A12 and other proteins of the aspartate-glutamate carrier (AGC) group are required for the transfer of mitochondrial aspartate to the cytosol, a key step in urea synthesis. Research studies using SLC25A12-knockout mice indicate that SLC25A12 plays an important role in proper CNS myelination. Mice lacking SLC25A12 suffer from hypomyelination as a result of a lack of oligodendrocyte maturation caused by decreased brain N-acetylaspartate levels. Mutation of the corresponding SLC25A12 gene can result in global cerebral hypomyelination and severe psychomotor retardation, caused by deficient SLC25A12 activity and limited mitochondrial aspartate efflux.

SLC25A12

O75746

Human; Rat; Mouse

Recombinant human SLC25A12 fragment

AGC; EIEE; SLC25A; SLC25A12; AGC1; ARALAR; EIEE39; ARALAR1; Araceli hiperlarga; Calcium binding mitochondrial carrier superfamily member; Calcium binding mitochondrial carrier superfamily member Aralar1; Calcium-binding mitochondrial carrier protein Aralar1; CMC1; member 12; Mitochondrial aspartate glutamate carrier 1; solute carrier family 25; Solute carrier family 25 (aspartate/glutamate carrier) member 12; Solute carrier family 25 (mitochondrial carrier Aralar) member 12; Solute carrier family 25 member 12

A655

Unconjugated

WB; IHC

Neuroscience; Tags & Cell Markers; Signal Transduction; Metabolism

Protein A purified

1 mg/mL

WB 1:2000-1:5000; IHC 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/1AhDQ6Xe

75 kDa

75 kDa

IgG, κ