Recombinant SLC7A5/LAT1 Monoklonale antilichamen

L-type amino acid transporter 1 (LAT1), also known as Solute carrier family 7 member 5 (SLC7A5), is a high-affinity neutral transporter of larger amino acids. It facilitates the cellular amino acid uptake in a sodium independent manner and selectively transports D-and L-isomers of small neutral amino acids. LAT1 also regulates amino acid exchange in conjunction with solute carrier family 1 member 5 (SLC1A5) . Transport of thyroid hormones across the placenta is established via LAT1 during normal fetal development. LAT1 promotes neuronal cell proliferation by regulating the transport of amino acids across the blood brain barrier. LAT1 is upregulated in various cancer types including breast cancer, lung cancer, prostate cancer, and gliomas. High expression of LAT1 is detected in non-small cell lung cancer with lymph node metastases. Increased LAT1 expression is a novel biomarker of high-grade malignancy in prostate cancers. Inhibition of LAT1 suppresses tumor cell growth in several tumor types.

SLC7A5/LAT1

Q01650

Human; Rat; Mouse

Recombinant human SLC7A5/LAT1 fragment

LAT; MPE; hLAT; SLC7A; SLC7A5;4F2LC; CD98; D16S469E; E16; LAT1; MPE16; hLAT1; CD98LC

A613

Unconjugated

WB; IHC

Signal Transduction; Metabolism

Protein A purified

1 mg/mL

WB 1:2000-1:10000; IHC 1:200-1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/y2UrWyI2

55 kDa

39 kDa

IgG, κ