Recombinant Thymidylaat Synthase Monoklonale Antilichaam

Thymidylate synthase is a homodimer composed of two 30 kDa subunits, which catalyze the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), an essential step in the formation of thymine nucleotides. Thymidylate synthase is an intracellular enzyme that provides the sole de novo source of thymidylate, making it a required enzyme in DNA biosynthesis with activity highest in proliferating cells. Being the exclusive source of dTMP, investigators have concluded that TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU) . 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head, and neck.

Thymidylate Synthase

P04818

Human; Rat; Mouse

Recombinant human Thymidylate Synthase fragment

HST; OK/SW-cl; TYMS; HST422; TMS; TS; thymidylate synthase; OK/SW-cl.29; HST422; thymidylate synthase; TMS; thymidylate synthetase

A524

Unconjugated

WB; IF; FCM

Epigenetics and Nuclear Signaling; Metabolism

Protein A purified

1 mg/mL

WB 1:500-1:2000; IF 1:50; FCM 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/b8mtwWbW

36 kDa

36 kDa

IgG, κ