Recombinant topo-isosomerase I Monoklonale antilichamen

DNA topoisomerases play essential roles in many DNA metabolic processes including DNA repair. Topoisomerases can introduce DNA damage upon exposure to drugs that stabilize the covalent protein-DNA intermediate of the topoisomerase reaction. Lesions in DNA are also able to trap topoisomerase-DNA intermediates. DNA topoisomerase I (Top1) catalyzes the relaxation of supercoiled DNA by a mechanism of transient DNA strand cleavage characterized by the formation of a phosphotyrosyl bond between the DNA end and active site tyrosine.

Topoisomerase I

P11387

Human; Rat; Mouse

Recombinant human Topoisomerase I fragment

TOP; TOP1; TOPI

A475

Unconjugated

WB; IHC; IF; FCM; IP

Epigenetics and Nuclear Signaling; Cancer

Protein A purified

1 mg/mL

WB 1:500-1:2000; IHC 1:100-1:500; IF 1:50; FCM 1:50-1:100; IP 1:25-1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/sV5hyHjB

91 kDa

108 kDa

IgG, κ