Recombinant Von Willebrand Factor Monoklonale Antilichaam

VWF (Von Willebrand factor) is a multimeric plasma glycoprotein that promotes adhesion of platelets to sites of vascular injury. Mature circulating VWF is made up of disulfide-bonded multimers that are in a complex with factor VIII. VWF is stored in secretory Weibel-Palade bodies in endothelial cells. It is synthesized as a large precursor protein and undergoes extensive posttranslational modifications including dimerization in the endoplasmic reticulum followed by cleavage of the pro-peptide and multimerization in the Golgi apparatus. VWF is important in hemostasis, and genetic defects in the structure and modification of VWF can cause von Willebrand disease (VWD), the most common congenital bleeding disorder in humans. Alternatively, increased levels of VWF have been shown to be involved in acute coronary thrombosis and are a clinical risk marker for atherosclerosis.

Von Willebrand Factor

Q8CIZ8

Human; Mouse

Recombinant human Von Willebrand Factor fragment

F8VWF; VWD; von Willebrand factor; von Willebrand antigen II; Vwf

A683

Unconjugated

WB; IHC

Protein A purified

1 mg/mL

WB 1:5000-1:10000; IHC 1:100-1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/iIJNz9wK

309 kDa

309 kDa

IgG, κ