Recombinante Fosfo-Stat5 (Tyr694) Monoklonale Antilichaam

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X (L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

STAT5a

P42229

Human

A synthetic phosphopeptide corresponding to residues around Tyr694 of human Phospho-Stat5.

MGF; STAT5; STAT5A; STA5A; Mammary gland factor; Signal transducer and activator of transcription 5A; STAT 5; STAT 5A

11G2

Unconjugated

WB

Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Metabolism

Protein A

1 mg/mL

WB 1:2000-1:200000

10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5

Ice bag

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

https://789.bio/eb/K3nzWMde

90 kDa

100 kDa

IgG