Recombinante glucocorticoïd Multiklonaal antilichaamontvanger

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175) .

Glucocorticoid Receptor

P04150

Human; Mouse; Rat

Recombinant Human Glucocorticoid Receptor protein

NR3C; nuclear receptor subfamily; glucocorticoid nuclear receptor variant; Nuclear receptor subfamily 3 group C member; GCCR; GCR; GCRST; GR; GRL; NR3C1; glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; Grl1; group C; member 1 (glucocorticoid receptor) ; nuclear receptor subfamily 3; Nuclear receptor subfamily 3 group C member 1

12B8

Unconjugated

WB; IHC

Epigenetics and Nuclear Signaling; Signal Transduction; Cancer

Protein A

0.2 mg/mL

IHC 1:1000-1:4000; WB 1:1000-1:5000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/wbuySXxu

85 kDa

94 kDa

IgG, κ