Recombinante muis FcRn/FCGRT-eiwit

Fcgrt, as known as IgG receptor FcRn large subunit p51, is a transmembrane glycoprotein with structural homology to MHC class 1 proteins. This protein is widely expressed in endothelial and epithelial cells and plays an important rloe in IgG homeostasis. Also, it is expessed in neutrophils and myeloid antigen presenting cells. It can enhance IgG-meditated phagocytosis and antigen presentation by heses cells, but it promotes the degradation of opsonizing IgG rather than returning it to the circulation. Recombinant mouse Fcgrt, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

IgG receptor FcRn large subunit p51, Fcgrt, FcRn, Fc gamma receptor and transporter, FcgammaRn, Transmembrane alpha chain of the neonatal receptor, Neonatal Fc receptor, FCRN alpha-chai

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

32.1 kDa (285aa)

IgG receptor FcRn large subunit p51, Fcgrt, FcRn, Fc gamma receptor and transporter, FcgammaRn, Transmembrane alpha chain of the neonatal receptor, Neonatal Fc receptor, FCRN alpha-chain, FCRN alpha chain, ATGP3485-10 µg, ATGP3485-20 µg, ATGP3485-50 µg, ATGP3485-100 µg, ATGP3485-250 µg, ATGP3485-500 µg, ATGP3485-1 mg, ATGP3485-010, ATGP3485-020, ATGP3485-050, ATGP3485-100, ATGP3485-250, ATGP3485-500, ATGP3485-01M

Baker K., et al, (2013) Immunity 39:1095-1107.; ; Paveglio S., et al, (2012) Clin. Exp. Allergy 42:1791-1800.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_034319.2

Q61559

Mouse

Ala

SETRPPL MYHLTAVSNP STGLPSFWAT GWLGPQQYLT YNSLRQEADP CGAWMWENQV SWYWEKETTD LKSKEQLFLE ALKTLEKILN GTYTLQGLLG CELASDNSSV PTAVFALNGE EFMKFNPRIG NWTGEWPETE IVANLWMKQP DAARKESEFL LNSCPERLLG HLERGRRNLE WKEPPSMRLK ARPGNSGSSV LTCAAFSFYP PELKFRFLRN GLASGSGNCS TGPNGDGSFH AWSLLEVKRG DEHHYQCQVE HEGLAQPLTV DLDSSARSS