Recombinante muis Kallikrein 8/KLK8 eiwit

Klk8, as known as kallikrein-8, is a member of the tissue kallikrein family. This protein is capable of degrading a number of proteins such as casein, fibrinogen, fibronectin and collagen type IV. Also, it cleaves L1CAM in response to increased neural activity and induces neurite outgrowth and fasciculation of cultured hippocampal neurons. It plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Recombinant mouse Klk8, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Kallikrein-8, Klk8, BSP1, NP, Nrpn, Prss19, Neuropsin, Kallikrein related peptidase 8, HNP, TADG14, neuropsin, ovasin

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

26.5 kDa (240aa)

BSP 1, BSP1, HNP, Kallikrein 8, Kallikrein related peptidase 8, Kallikrein related peptidase8, Kallikrein8, Kallikrein-8, Klk 8, Klk8, Neuropsin, NP, Nrpn, Ovasin, Prss 19, Prss19, TADG 14, TADG14, ATGP3553-10 µg, ATGP3553-20 µg, ATGP3553-50 µg, ATGP3553-100 µg, ATGP3553-250 µg, ATGP3553-500 µg, ATGP3553-1 mg, ATGP3553-010, ATGP3553-020, ATGP3553-050, ATGP3553-100, ATGP3553-250, ATGP3553-500, ATGP3553-01M

Kishibe M., et al, (2012) J. Invest. Dermatol. 132:1717-1724.; ; Attwood BK., et al, (2011) Nature 473:372-375.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_032966

Q61955

Mouse

Gln29