Recombinante muis Lactadherine/MFGE8 eiwit

Mfge8, also known as Milk fat globule-EGF factor 8 protein, is pleiotropic secreted glycoprotein that promotes mammary gland morphogenesis, angiogenesis, and tumor progression. It also plays an important role in tissue homeostasis and the prevention of inflammation. It functions as a bridge between phosphatidylserine on apoptotic cells and Integrin alpha V beta 3 on phagocytes, leading to the clearance of apoptotic debris. Recombinant mouse Mfge8 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Milk fat globule EGF and factor V/VIII domain containing, EGF/factor VIII, Lactadherin, MFG-E8, Mfgm, SED1

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

46kDa (413aa)

AA408458, AI325141, EGF/factor VIII, Lactadherin, Mfge8, MFG-E8, Mfgm, Milk fat globule EGF and factor V/VIII domain containing, Milk fat globule-EGF factor 8 protein, MP47, P47, SED1, ATGP3511-10 µg, ATGP3511-20 µg, ATGP3511-50 µg, ATGP3511-100 µg, ATGP3511-250 µg, ATGP3511-500 µg, ATGP3511-1 mg, ATGP3511-010, ATGP3511-020, ATGP3511-050, ATGP3511-100, ATGP3511-250, ATGP3511-500, ATGP3511-01M

Oba J., et al. (2011) Br J Dermatol. 165: 506-512.; ; Liu F., et al. (2014) Stroke. 45: 3691-3697.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Apoptosis

NP_001038954

Q3TDU5

Mouse

Ala

ASGDFCD SSLCLNGGTC LTGQDNDIYC LCPEGFTGLV CNETERGPCS PNPCYNDAKC LVTLDTQRGD IFTEYICQCP VGYSGIHCET GCSTQLGMEG GAIADSQISA SSVYMGFMGL QRWGPELARL YRTGIVNAWT ASNYDSKPWI QVNLLRKMRV SGVMTQGASR AGRAEYLKTF KVAYSLDGRK FEFIQDESGG DKEFLGNLDN NSLKVNMFNP TLEAQYIKLY PVSCHRGCTL RFELLGCELH GCSEPLGLKN NTIPDSQMSA SSSYKTWNLR AFGWYPHLGR LDNQGKINAW TAQSNSAKEW LQVDLGTQRQ VTGIITQGAR DFGHIQYVAS YKVAHSDDGV QWTVYEEQGS SKVFQGNLDN NSHKKNIFEK PFMARYVRVL PVSWHNRITL RLELLGC