Recombinante muis TRANCE/RANKL/TNFSF11-eiwit

TRANCE, also known as tumor necrosis factor ligand superfamily member 11, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. TRANCE also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation. TRANCE is important in bone metabolism. This natural and necessary surface-bound molecule (also known as CD254) found on osteoblasts serves to activate osteoclasts, which are the cells involved in bone resorption. Recombinant Mouse TRANCE protein was expressed in E. coli and purified by using conventional chromatography.

Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, RANKL, TNF-related activation-induced cytokine, TRANCE, CD254

E.coli

Mouse

Non-Tagged

SDS-PAGE

1 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

17.9 kDa (160aa) confirmed by MALDI-TOF

TRANCE, RANK L, TNFSF11, ATGP3851-10 µg, ATGP3851-20 µg, ATGP3851-50 µg, ATGP3851-100 µg, ATGP3851-250 µg, ATGP3851-500 µg, ATGP3851-1 mg, ATGP3851-10, ATGP3851-20, ATGP3851-50, ATGP3851-100, ATGP3851-250, ATGP3851-500, ATGP3851-1

Lam J., et al. (2001) . J. Clin. Invest. 108 (7) :971-9; ; Ito S., et al. (2002) . J. Biol. Chem. 277 (8) :6631-6

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid In. 20 mM Tris-HCl buffer (pH8.5) containing 0.1M NaCl

Hormones & Cytokines

NP_035743

O35235

Mouse

MKPEAQPFAH LTINAASIPS GSHKVTLSSW YHDRGWAKIS NMTLSNGKLR VNQDGFYYLY ANICFRHHET SGSVPTDYLQ LMVYVVKTSI KIPSSHNLMK GGSTKNWSGN SEFHFYSINV GGFFKLRAGE EISIQVSNPS LLDPDQDATY FGAFKVQDID