Recombinante muis VE-Cadherine/CDH5-eiwit

CDH5, also known as cadherin-5, is a classical cadherin from the cadherin superfamily and the gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Recombinant mouse CDH5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Cdh5, 7B4, AA408225, Cd144, VE-Cad, Vec, VEcad, VECD, Vascular endothelial cadherin

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

66.2 kDa (583aa)

Cadherin5, Cdh5, 7B4, AA408225, Cd144, VE-Cad, Vec, VEcad, VECD, ATGP3209-10 µg, ATGP3209-20 µg, ATGP3209-50 µg, ATGP3209-100 µg, ATGP3209-250 µg, ATGP3209-500 µg, ATGP3209-1 mg, ATGP3209-10, ATGP3209-20, ATGP3209-50, ATGP3209-100, ATGP3209-250, ATGP3209-500, ATGP3209-1

Matsuyoshi N., et al. (1997) Proc Assoc Am Physicians. 109:362-371.; ; Duguay D., et al. (2003) Dev Biol. 253:309-23.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_033998.2

P55284

Mouse