Recombinante rat CCL2/MCP-1-eiwit

Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1) . CCL2 recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. It binds to chemokine receptors CCR2 and CCR4. It also induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils, primarily due to interaction with CCR2 receptors on these cells. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. Recombinant rat CCL2/JE/MCP-1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

C-C motif chemokine 2, HC11, JE, MCAF, MCP-1, MCP1, Scya2, Sigje, SMC-CF, Immediate-early serum-responsive protein JE, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, Small-inducible cytokine A2

Baculovirus

Rat

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

15.1kDa (134aa)

ATGP4002-10 µg, ATGP4002-50 µg, ATGP4002-100 µg, ATGP4002-200ug, ATGP4002-250 µg, ATGP4002-500 µg, ATGP4002-1 mg, ATGP4002-10 µg, ATGP4002-20 µg, ATGP4002-50 µg, ATGP4002-100 µg, ATGP4002-250 µg, ATGP4002-500 µg, ATGP4002-1 mg, ATGP4002-10, ATGP4002-20, ATGP4002-50, ATGP4002-100, ATGP4002-250, ATGP4002-500, ATGP4002-1

Foresti ML, Arisi GM, et al. (2009) . J Neuroinflammation. 6:40.; ; Semple BD, Bye N, et al. (2010) . J Cereb Blood Flow Metab. 30:769-782.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology, Hormones & Cytokines

NP_113718

P14844

Rat

Ala

QPDAVNA PLTCCYSFTG KMIPMSRLEN YKRITSSRCP KEAVVFVTKL KREICADPNK EWVQKYIRKL DQNQVRSETT VFYKIASTLR TSAPLNVNLT HKSEANASTL FSTTTSSTSV EVTSMTEN